Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. - Wikidata - awgldk - TriplyDB

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

http://www.wikidata.org/entity/Q37555261

about

Analysis of gene amplification in human tumor cell lines.A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.Expression of a multidrug-resistance gene in human tumors and tissues Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine Pharmacogenetics in diverse ethnic populations--implications for drug discovery and development.Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo.DNA amplification in multidrug, cross-resistant Chinese hamster ovary cells: molecular characterization and cytogenetic localization of the amplified DNA The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.Formation of an inverted duplication can be an initial step in gene amplification.Chromosome-mediated gene transfer of multidrug resistance.Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.Multidrug-resistant phenotype cosegregates with an amplified gene in somatic cell hybrids of drug-resistant Chinese hamster ovary cells and drug-sensitive murine cells Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.The clinical relevance of multidrug resistance.DNA amplification is rare in normal human cells.Importance of detecting multidrug resistance proteins in acute leukemia prognosis and therapy.Cystic fibrosis transmembrane conductance regulator (ABCC7) structure Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multidrug-resistant cells.Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains Predictors of response of acute nonlymphocytic leukemia.P-glycoprotein: clinical significance and methods of analysis.Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.Drug-induced loss of unstably amplified genes.A phase II study of cisplatinum versus cisplatinum + nifedipine in end-stage carcinoma of the head and neck.MDR1 transcript levels as an indication of resistant disease in acute myelogenous leukaemia.Expression of the multidrug resistance gene (MDR1) in non-small cell lung cancer.

P2860

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P2860

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

http://www.wikidata.org/entity/Q37555261

description

1985 nî lūn-bûn

@nan

1985年の論文

@ja

1985年学术文章

@wuu

1985年学术文章

@zh-cn

1985年学术文章

@zh-hans

1985年学术文章

@zh-my

1985年学术文章

@zh-sg

1985年學術文章

@yue

1985年學術文章

@zh

1985年學術文章

@zh-hant

name

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@en

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@nl

type

label

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@en

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@nl

prefLabel

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@en

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@nl

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PNAS.82.22.7661

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

@en

P2093

Fojo AT

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Gottesman MM

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Pastan I

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Whang-Peng J

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P2860

Amplification of a cloned Chinese hamster dihydrofolate reductase gene after transfer into a dihydrofolate reductase-deficient cell line

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments

Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes.

Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.

Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells.

Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells.

Drug resistance in Chinese hamster lung and mouse tumor cells.

Vinca alkaloid-resistant phenotype in cultured human leukemic lymphoblasts.

Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels.

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7661-7665

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scholarly article

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10.1073/PNAS.82.22.7661

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3865187

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multiple drug resistance

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