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Mechanisms of gene duplication and amplificationProto-oncogene activation and genomic instability of cadmium-induced cell transformation in BALB/c-3T3 cellsInherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquineAmplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaksInherited DNA amplification of the proximal 15q region: cytogenetic and molecular studies.Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakageTargeted expression of MYCN causes neuroblastoma in transgenic mice.Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair systemHigh rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.A spontaneous chromosomal amplification of the ADH2 gene in Saccharomyces cerevisiae.MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.p53-dependent growth arrest of REF52 cells containing newly amplified DNA.Role of proto-oncogene activation in carcinogenesis.Pharmacogenetics: the slow, the rapid, and the ultrarapid.Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin.DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene.Genomic instability and bystander effects induced by high-LET radiation.Elements which stimulate gene amplification in mammalian cells: role of recombinogenic sequences/structures and transcriptional activationExpression of growth factor receptors in human brain tumours.Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged.Human chromosome 3 mediates growth arrest and suppression of apoptosis in microcell hybrids.Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells.Polyomavirus DNA replication in the pancreas and in a transformed pancreas cell line has distinct enhancer requirementsCross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNAEffects of genome position and the DNA damage checkpoint on the structure and frequency of sod2 gene amplification in fission yeastRelationship of eukaryotic DNA replication to committed gene expression: general theory for gene controlSimian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification.Genetic and environmental modulations of chromosomal stability: their roles in aging and oncogenesis.Nucleoside salvage and resistance to antimetabolite anticancer agents.Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment.Genetic mechanisms of drug resistance. A review.Normal diploid human and rodent cells lack a detectable frequency of gene amplification.Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system.Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α' levels.Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.Transferable Streptomyces DNA amplification and coamplification of foreign DNA sequences.Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax.Multiple pathways leading to genomic instability and tumorigenesis.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
DNA amplification is rare in normal human cells.
@en
DNA amplification is rare in normal human cells.
@nl
type
label
DNA amplification is rare in normal human cells.
@en
DNA amplification is rare in normal human cells.
@nl
prefLabel
DNA amplification is rare in normal human cells.
@en
DNA amplification is rare in normal human cells.
@nl
P2093
P2860
P356
P1476
DNA amplification is rare in normal human cells.
@en
P2093
D L Hudson
J A Wright
M C Hancock
P2860
P304
P356
10.1073/PNAS.87.5.1791
P407
P50
P577
1990-03-01T00:00:00Z