The human BCL6 transgene promotes the development of lymphomas in the mouse
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Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targetsRepression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomasA Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In VivoFBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomasBCL6 modulation of acute lymphoblastic leukemia response to chemotherapyGenetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complexNek2 is a novel regulator of B cell development and immunological response.GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomasTranscriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomasA Network Model to Describe the Terminal Differentiation of B CellsPredicting the effect of transcription therapy in hematologic malignancies.The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.CtBP is an essential corepressor for BCL6 autoregulation.Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphomaReversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells.BCL6 expression correlates with monomorphic histology in children with posttransplantation lymphoproliferative disease.Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas.A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivoB-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cellsBCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells.miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma.BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis.The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target.Sequential transcription factor targeting for diffuse large B-cell lymphomas.BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner.Association of Ig/BCL6 translocations with germinal center B lymphocytes in human lymphoid tissues: implications for malignant transformation.Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice.
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The human BCL6 transgene promotes the development of lymphomas in the mouse
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 September 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The human BCL6 transgene promotes the development of lymphomas in the mouse
@en
The human BCL6 transgene promotes the development of lymphomas in the mouse.
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type
label
The human BCL6 transgene promotes the development of lymphomas in the mouse
@en
The human BCL6 transgene promotes the development of lymphomas in the mouse.
@nl
prefLabel
The human BCL6 transgene promotes the development of lymphomas in the mouse
@en
The human BCL6 transgene promotes the development of lymphomas in the mouse.
@nl
P2093
P2860
P356
P1476
The human BCL6 transgene promotes the development of lymphomas in the mouse
@en
P2093
Anthony Montag
Beverly W Baron
Dean W Felsher
Dezheng Huo
John Anastasi
Joseph M Baron
Michael J Thirman
Rebecca M Baron
Robert K Chin
Sumit K Subudhi
P2860
P304
14198-14203
P356
10.1073/PNAS.0406138101
P407
P577
2004-09-16T00:00:00Z