Requirement of c-myb in T cell development and in mature T cell function. - Wikidata - awgldk - TriplyDB

Requirement of c-myb in T cell development and in mature T cell function.

Requirement of c-myb in T cell development and in mature T cell function.

http://www.wikidata.org/entity/Q37570509

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c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL Identification of novel genes and transcription factors involved in spleen, thymus and immunological development and function.c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.Impact of the c-MybE308G mutation on mouse myelopoiesis and dendritic cell development.Selected microRNAs define cell fate determination of murine central memory CD8 T cells.Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression.p89c-Myb is not required for fetal or adult hematopoiesis From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Myb permits multilineage airway epithelial cell differentiation.Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells.Alu elements mediate MYB gene tandem duplication in human T-ALL Progress in multiple sclerosis genetics.Launching the T-cell-lineage developmental programme The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells.Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4.Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3 Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.A plasma microRNA signature as a biomarker for acquired aplastic anemia.B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4.The network of transcription factors that underlie the CD4 versus CD8 lineage decision.Transcriptional control of T-cell development.Transcriptional control of early T and B cell developmental choices Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias.Transcription factors and target genes of pre-TCR signaling.c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus.miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.Myb proteins regulate expression of histone variant H2A.Z during thymocyte development.Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms.c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation

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Requirement of c-myb in T cell development and in mature T cell function.

http://www.wikidata.org/entity/Q37570509

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 04 October 2004

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Requirement of c-myb in T cell development and in mature T cell function.

@en

Requirement of c-myb in T cell development and in mature T cell function.

@nl

type

label

Requirement of c-myb in T cell development and in mature T cell function.

@en

Requirement of c-myb in T cell development and in mature T cell function.

@nl

prefLabel

Requirement of c-myb in T cell development and in mature T cell function.

@en

Requirement of c-myb in T cell development and in mature T cell function.

@nl

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PNAS.0405338101

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Proceedings of the National Academy of Sciences of the United States of America

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Requirement of c-myb in T cell development and in mature T cell function.

@en

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Anthony G Pajerowski

http://www.w3.org/2001/XMLSchema#string

Atul Kumar

http://www.w3.org/2001/XMLSchema#string

E Premkumar Reddy

http://www.w3.org/2001/XMLSchema#string

Thomas J Rogers

http://www.w3.org/2001/XMLSchema#string

Yen K Lieu

http://www.w3.org/2001/XMLSchema#string

P2860

The myb gene family in cell growth, differentiation and apoptosis

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

Critical functions for c-Myb at three checkpoints during thymocyte development.

c-Myb is essential for early T cell development.

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination

Identification and characterization of the protein encoded by the human c-myb proto-oncogene.

Molecular and cellular mechanisms of T cell development.

Regulation of T lymphocyte proliferation. Interleukin 2-mediated induction of c-myb gene expression is dependent on T lymphocyte activation state.

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14853-14858

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scholarly article

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10.1073/PNAS.0405338101

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41

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101

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2004-10-04T00:00:00Z

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15466706

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522009

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