Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
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Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolitesAccessing Nature's diversity through metabolic engineering and synthetic biologyRecent Advances in Understanding and Engineering Polyketide SynthesisThe Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine MicroorganismsAntimicrobial peptides in 2014Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pecDirected natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilisMolecules to Ecosystems: Actinomycete Natural Products In situCritical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway.Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China.Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system.Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.Roles of type II thioesterases and their application for secondary metabolite yield improvement.Mining the metabiome: identifying novel natural products from microbial communities.Antibiotics and the gut microbiota.Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces.Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitorsMining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study.Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform.Strain-level diversity of secondary metabolism in Streptomyces albusMinimum Information about a Biosynthetic Gene cluster.Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.Technology development for natural product biosynthesis in Saccharomyces cerevisiae.Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters.Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system.Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster.Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactinMultiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.Using natural products for drug discovery: the impact of the genomics era.In Vitro CRISPR/Cas9 System for Efficient Targeted DNA Editing.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Reinvigorating natural product combinatorial biosynthesis with synthetic biologyIdentification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining"Cre/loxP plus BAC": a strategy for direct cloning of large DNA fragment and its applications in Photorhabdus luminescens and Agrobacterium tumefaciens.Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.
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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 January 2014
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@en
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@nl
type
label
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@en
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@nl
prefLabel
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@en
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@nl
P2093
P2860
P50
P356
P1476
Direct cloning and refactoring ...... ds the antibiotic taromycin A.
@en
P2093
David J Gonzalez
Katherine S Ryan
Kirk A Reynolds
Pieter C Dorrestein
Roland D Kersten
P2860
P304
P356
10.1073/PNAS.1319584111
P407
P577
2014-01-21T00:00:00Z