Structural stability in the 4-zinc human insulin hexamer.
about
A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helixDesign of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONSThe structure of a complex of hexameric insulin and 4'-hydroxyacetanilideCrystal structure of desheptapeptide(B24-B30)insulin at 1.6 A resolution: implications for receptor bindingRoles of Zinc Signaling in the Immune SystemFlexibility in crystalline insulins.Effects of localized interactions and surface properties on stability of protein-based therapeutics.A novel complex of a phenolic derivative with insulin: structural features related to the T-->R transition.Atomic force microscopy of insulin single crystals: direct visualization of molecules and crystal growth.GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells.Atomic force microscopy of crystalline insulins: the influence of sequence variation on crystallization and interfacial structure.Structural and morphological characterization of ultralente insulin crystals by atomic force microscopy: evidence of hydrophobically driven assembly.Structural studies of a crystalline insulin analog complex with protamine by atomic force microscopy.Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometryDiabetes mellitus and closed-loop insulin delivery.Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.Enhanced insulin absorption from sublingual microemulsions: effect of permeation enhancers.Exploring molecular and mechanical gradients in structural bioscaffoldsThe structure and function of insulin: decoding the TR transitionHuman insulin polymorphism upon ligand binding and pH variation: the case of 4-ethylresorcinol.Zinc and insulin in pancreatic beta-cells.Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamics.Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.Zinc-induced changes in ionic currents of clonal rat pancreatic -cells: activation of ATP-sensitive K+ channels.Analysis of zinc binding sites in protein crystal structures.Ligand perturbation effects on a pseudotetrahedral Co(II)(His)3-ligand site. A magnetic circular dichroism study of the Co(II)-substituted insulin hexamer.Comparison of NMR and Dynamic Light Scattering for Measuring Diffusion Coefficients of Formulated Insulin: Implications for Particle Size Distribution Measurements in Drug Products.Measuring biotherapeutic viscosity and degradation on-chip with particle diffusometry.Effects of cysteic acid groups on the gas-phase reactivity and dissociation of [M + 4H]4+ ions from insulin chain B.
P2860
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P2860
Structural stability in the 4-zinc human insulin hexamer.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Structural stability in the 4-zinc human insulin hexamer.
@en
Structural stability in the 4-zinc human insulin hexamer.
@nl
type
label
Structural stability in the 4-zinc human insulin hexamer.
@en
Structural stability in the 4-zinc human insulin hexamer.
@nl
prefLabel
Structural stability in the 4-zinc human insulin hexamer.
@en
Structural stability in the 4-zinc human insulin hexamer.
@nl
P2093
P2860
P356
P1476
Structural stability in the 4-zinc human insulin hexamer.
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.22.7093
P407
P577
1984-11-01T00:00:00Z