MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. - Wikidata - awgldk - TriplyDB

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

http://www.wikidata.org/entity/Q37588178

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Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease New therapeutic strategies for BRAF mutant colorectal cancers MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer Replicative DNA polymerase mutations in cancer Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients.Hypermutation in human cancer genomes: footprints and mechanisms Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach Microsatellite instable vs stable colon carcinomas: analysis of tumour heterogeneity, inflammation and angiogenesis Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data Gastrointestinal tract cancers: Genetics, heritability and germ line mutations Genetic predisposition to colorectal cancer: where we stand and future perspectives Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks.How Can Next-Generation Sequencing (Genomics) Help Us in Treating Colorectal Cancer?Predictors of Chemosensitivity in Triple Negative Breast Cancer: An Integrated Genomic Analysis.Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors.Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance Distinct features between MLH1-methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway.Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.Important molecular genetic markers of colorectal cancer.The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer.Precision medicine in colorectal cancer: evolving genomic landscape and emerging consensus.Loss of MutL Disrupts Chk2-dependent Cell Cycle Control Through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer.The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer.Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications.MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.Aberrant methylation of mutL homolog 1 is associated with increased risk of non-small cell lung cancer.Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.Evaluating intrinsic and non-intrinsic cancer risk factors

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MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.

http://www.wikidata.org/entity/Q37588178

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@en

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@nl

type

label

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@en

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@nl

prefLabel

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@en

MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@nl

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The Journal of Pathology

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MLH1-silenced and non-silenced ...... istinct mutational landscapes.

@en

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Chad J Creighton

http://www.w3.org/2001/XMLSchema#string

Chris Sander

http://www.w3.org/2001/XMLSchema#string

David Wheeler

http://www.w3.org/2001/XMLSchema#string

Eve Shinbrot

http://www.w3.org/2001/XMLSchema#string

Lawrence A Donehower

http://www.w3.org/2001/XMLSchema#string

Preethi H Gunaratne

http://www.w3.org/2001/XMLSchema#string

Richard A Gibbs

http://www.w3.org/2001/XMLSchema#string

Stanley R Hamilton

http://www.w3.org/2001/XMLSchema#string

P2860

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

Microsatellite instability in colorectal cancer

Comprehensive molecular characterization of human colon and rectal cancer

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers

CpG island methylator phenotype in colorectal cancer

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

The consensus coding sequences of human breast and colorectal cancers

The genomic landscapes of human breast and colorectal cancers

Eukaryotic DNA mismatch repair.

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99-110

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scholarly article

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10.1002/PATH.4087

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1

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229

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Nikolaus Schultz

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2013-01-01T00:00:00Z

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22899370

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3926301

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