Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
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Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption.The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR functionASD: a comprehensive database of allosteric proteins and modulatorsAlpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicologyOrthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking CessationNeuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to NicotineIon channels gated by acetylcholine and serotonin: structures, biology, and drug discoveryOptogenetic studies of nicotinic contributions to cholinergic signaling in the central nervous systemAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsDrugs for allosteric sites on receptorsThe neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition.Conformational transition pathway in the activation process of allosteric glucokinaseEnantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding ProteinInsights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent CationsStructure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholineAssembly of a π–π stack of ligands in the binding site of an acetylcholine-binding proteinA locally closed conformation of a bacterial pentameric proton-gated ion channelMolecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptorsTargeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptorsBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculationsA Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationSignal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion ChannelsStructural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptorsNicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disordersPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning.Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors.Nicotinic filtering of sensory processing in auditory cortexThe Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex.Real time ligand-induced motion mappings of AChBP and nAChR using X-ray single molecule trackingA synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors.Conotoxins targeting nicotinic acetylcholine receptors: an overviewDiscovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.
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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Nicotinic receptors: allosteri ...... targets in the nervous system.
@en
Nicotinic receptors: allosteri ...... targets in the nervous system.
@nl
type
label
Nicotinic receptors: allosteri ...... targets in the nervous system.
@en
Nicotinic receptors: allosteri ...... targets in the nervous system.
@nl
prefLabel
Nicotinic receptors: allosteri ...... targets in the nervous system.
@en
Nicotinic receptors: allosteri ...... targets in the nervous system.
@nl
P2093
P356
P1476
Nicotinic receptors: allosteri ...... targets in the nervous system.
@en
P2093
Antoine Taly
Denis Guedin
Jean-Pierre Changeux
Pierre Lestage
Pierre-Jean Corringer
P2888
P304
P356
10.1038/NRD2927
P577
2009-09-01T00:00:00Z
P5875
P6179
1049839544