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Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expressionInsulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cellsKnockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotesHypermutation induced by APOBEC-1 overexpression can be eliminatedA study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenariansThe roles of genetic polymorphisms and human immunodeficiency virus infection in lipid metabolismIdentification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editingNovel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factorARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editingApolipoprotein[a] secretion from hepatoma cells is regulated in a size-dependent manner by alterations in disulfide bond formationApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme componentsTargeted capture and resequencing of 1040 genes reveal environmentally driven functional variation in grey wolvesMutagenesis of apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, reveals distinct domains that mediate cytosine nucleoside deaminase, RNA binding, and RNA editing activityPhosphorylation is a regulatory mechanism in apolipoprotein B mRNA editingapo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotesA novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout miceReduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncationSusceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100Developmental regulation of apolipoprotein B mRNA editing is an autonomous function of small intestine involving homeobox gene Cdx1Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in miceLipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" miceTargeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestineIdentification of two common variants contributing to serum apolipoprotein B levels in Mexicans.Why are low-density lipoproteins atherogenic?An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability.Expression of apolipoprotein B in the kidney attenuates renal lipid accumulationAnalysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice.Accumulation of "small dense" low density lipoproteins (LDL) in a homozygous patients with familial defective apolipoprotein B-100 results from heterogenous interaction of LDL subfractions with the LDL receptor.Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).Use of immunoelectron microscopy and intestinal models to explore the elaboration of apolipoproteins required for intraenterocyte lipid transport.Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animalsIn vivo genome editing using Staphylococcus aureus Cas9A truncated species of apolipoprotein B (B67) in a kindred with familial hypobetalipoproteinemia.Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.Lipoproteins containing the truncated apolipoprotein, Apo B-89, are cleared from human plasma more rapidly than Apo B-100-containing lipoproteins in vivo.Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantationLiver fibrosis in a patient with familial homozygous hypobetalipoproteinaemia: possible role of vitamin supplementation.Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humansUnleashing the untold and misunderstood observations on vitamin E.
P2860
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P2860
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Recent progress in understanding apolipoprotein B.
@en
Recent progress in understanding apolipoprotein B.
@nl
type
label
Recent progress in understanding apolipoprotein B.
@en
Recent progress in understanding apolipoprotein B.
@nl
prefLabel
Recent progress in understanding apolipoprotein B.
@en
Recent progress in understanding apolipoprotein B.
@nl
P356
P1433
P1476
Recent progress in understanding apolipoprotein B
@en
P2093
P304
P356
10.1161/01.CIR.82.5.1574
P407
P577
1990-11-01T00:00:00Z