High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.
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In vivo acetylation identified at lysine 70 of human lens alphaA-crystallinIdentification and quantification of major maillard cross-links in human serum albumin and lens protein. Evidence for glucosepane as the dominant compoundN-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteinsThe LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesisInsulin-like growth factor 1, glycation and bone fragility: implications for fracture resistance of boneRacemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lensesAGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells: implications for age-associated fibrosisMaillard degradation pathways of vitamin C.Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model.Lack of effect of copper on advanced Maillard reaction and glucose autoxidation at physiological concentrations of albumin.Protective effects of carnosine on dehydroascorbate-induced structural alteration and opacity of lens crystallins: important implications of carnosine pleiotropic functions to combat cataractogenesis.Structure elucidation of a novel yellow chromophore from human lens protein.3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.Characterization of covalent multimers of crystallins in aging human lenses.Early glycation products produce pentosidine cross-links on native proteins. novel mechanism of pentosidine formation and propagation of glycation.Deamidation affects structural and functional properties of human alphaA-crystallin and its oligomerization with alphaB-crystallin.Spectroscopic and biochemical correlations during the course of human lens aging.Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labeling.UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation.Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry.Iron, the retina and the lens: a focused review.Phosphoproteomics characterization of novel phosphorylated sites of lens proteins from normal and cataractous human eye lensesThe biology of aging and frailty.Ocular complications of diabetes mellitus.Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug developmentVitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model.Advanced glycation end products in diabetic and non-diabetic human subjects suffering from cataract.Determination of dideoxyosone precursors of AGEs in human lens proteins.Vitamin C degradation products and pathways in the human lensAdvanced Maillard reaction end products are associated with Alzheimer disease pathologySkin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataractAnalysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation.UV-A-induced structural and functional changes in human lens deamidated alphaB-crystallin.Chemical modulation of the chaperone function of human alphaA-crystallin.Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse LensChaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataractsMultispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigensInhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging.Structural alterations of human serum albumin caused by glycative and oxidative stressors revealed by circular dichroism analysis
P2860
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P2860
High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh
1991年學術文章
@zh-hant
name
High correlation between pento ...... nescence and cataractogenesis.
@en
High correlation between pento ...... nescence and cataractogenesis.
@nl
type
label
High correlation between pento ...... nescence and cataractogenesis.
@en
High correlation between pento ...... nescence and cataractogenesis.
@nl
prefLabel
High correlation between pento ...... nescence and cataractogenesis.
@en
High correlation between pento ...... nescence and cataractogenesis.
@nl
P2093
P2860
P356
P1476
High correlation between pento ...... nescence and cataractogenesis.
@en
P2093
B J Ortwerth
M Prabhakaram
R H Nagaraj
V M Monnier
P2860
P304
10257-10261
P356
10.1073/PNAS.88.22.10257
P407
P577
1991-11-01T00:00:00Z