Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans - Wikidata - awgldk - TriplyDB

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

http://www.wikidata.org/entity/Q37624894

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Circulating mitochondrial biomarkers for drug-induced liver injury Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.Pharmacologic cholinesterase inhibition improves survival in acetaminophen-induced acute liver failure in the mouse Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells.Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.Translational biomarkers of acetaminophen-induced acute liver injury Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.The Effect of Copper And Zinc Nanoparticles on the Growth Parameters, Contents of Ascorbic Acid, and Qualitative Composition of Amino Acids and Acylcarnitines in Pistia stratiotes L. (Araceae).Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity.Inflammasome activation and function in liver disease.Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?The past and present of serum aminotransferases and the future of liver injury biomarkers.A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver PPARα activation protects against cholestatic liver injury.Prophylactic and Therapeutic Potential of Acetyl-L-carnitine against Acetaminophen-Induced Hepatotoxicity in Mice.Highlight report: biomarkers of acetaminophen-induced liver injury.ATM directs DNA damage responses and proteostasis via genetically separable pathways.Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice.The Opportunities of Metabolomics in Drug Safety Evaluation.Highlight report: acetaminophen hepatotoxicity.Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.

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Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans

http://www.wikidata.org/entity/Q37624894

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Circulating acylcarnitines as ...... en overdose in mice and humans

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Circulating acylcarnitines as ...... en overdose in mice and humans

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Circulating acylcarnitines as ...... en overdose in mice and humans

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S00204-013-1118-1

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Archives of Toxicology

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Circulating acylcarnitines as ...... en overdose in mice and humans

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C David Williams

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Feng Li

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Hartmut Jaeschke

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Matthew R Sharpe

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Steven C Curry

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Xiaochao Ma

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P2860

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

Fatty acid oxidation disorders.

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

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s00204-013-1118-1

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scholarly article

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10.1007/S00204-013-1118-1

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Mitchell R McGill

Mitchell R McGill

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2013-08-25T00:00:00Z

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256119892

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