t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
about
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaIsoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk geneA novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cellsSubcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBFTranscriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressorsThe PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasiaIdentification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactionsFusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemiaThe AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion proteinETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domainOligomerization of ETO is obligatory for corepressor interactionThe 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcriptDisruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisGeneration of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemiaAlternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemiaIdentification of AML1-ETO modulators by chemical genomicsA RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasiaETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complexAn important role for RUNX3 in human L1 transcription and retrotranspositionAnalysis of chromosome 21 yeast artificial chromosome (YAC) clonesAML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocationAction mechanisms of histone deacetylase inhibitors in the treatment of hematological malignanciesNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Transcriptional network control of normal and leukaemic haematopoiesisIsoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1Microglia development and functionA TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcriptionStructure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activityAssociation of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell linesA mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemiaAML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoterNuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)AML1 interconnected pathways of leukemogenesisMTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytesMutational analyses of the AML1 gene in patients with myelodysplastic syndromeFamilial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemiaELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO
P2860
Q22254263-358D49B7-CF46-4F20-AAEF-885764F76440Q24309536-DCD2C8D8-7B68-4AAC-8121-0C7E84C96905Q24312874-7FA32274-4D4A-48C8-896F-265A798AFBA8Q24314024-FDDCAF48-7E62-4CF9-8651-678C35BBB54EQ24316983-1FAE6701-2AA8-4CBA-9B44-69744D426B01Q24317100-54466CB3-5CF4-4124-836F-37200B31D2B7Q24318843-5276EECE-8BAC-49B9-A38F-FE06DC4F9CE2Q24319864-47E0281F-567E-4CC4-BB67-353B525A5159Q24324229-E9064E5D-337C-4AED-98A1-DE268C40AC81Q24522515-27ED8C68-9DB7-474D-A278-13D8395AD3BAQ24548340-0F689CBA-5405-4183-ADB0-0EFDE2AB29E4Q24550754-3037B5FB-5781-4FAA-BB40-B6F2ED0E5A62Q24561767-A0DECB93-3B1F-40C0-9285-F253F0A235A3Q24564573-5663070C-B409-4F95-8910-B72E562EBAEDQ24567977-59BA4F5F-74CC-4604-B867-9CE5B2DD94ECQ24596770-3AF42A92-E2AA-4241-A452-976C851CACD3Q24626212-975EBC3A-64BB-4A41-AF2E-64C5C35BF79CQ24643359-5AA7F975-94A6-4035-8B97-BAF3BC1A3EADQ24652629-3D7023D8-53A4-4B6C-9613-C423B17727C7Q24653699-254F2CE9-D14F-4407-8C4C-0EB15689A1E2Q24670621-AB672E37-607A-466D-BEC2-47AC675C2DBDQ24679560-ED388FF0-679E-4AE9-94C6-2FDE96B2BBA4Q24681049-D6B9BD45-600E-45FD-BA9E-B288125841BCQ26739689-6143FAF0-E68B-4242-B2E4-DA87BEA75C5FQ26777988-85CB26ED-37B9-4A71-B51C-C5B3D54E4381Q27005940-50666B78-29D0-4963-9A81-94295289F3A3Q27307661-DC5066E1-8F3B-40C3-A89E-F650DE7A9352Q27316453-34C6CF30-373B-40B1-B078-39EA9C4052E7Q27645941-63EE7249-D314-4DD9-B3B4-5B3E8A06FC99Q27653703-96DBE439-9700-4F10-8058-4FE5EA0615FCQ27664050-375E3F03-904A-4921-BE60-4105E590D068Q28138744-62785B56-3B08-4EDB-B54B-8EDD1B9A981BQ28141676-CDF73B99-B8D9-4101-AEB6-30534A267814Q28142631-4C059510-19D5-437E-86A4-3663DCAAC11EQ28144264-59A0B59A-0DC3-4B3C-BADE-92C6DF16FBA4Q28184349-6D1C9F99-02CB-4DC5-9E1B-57E166B31D4FQ28191156-E118936E-35F8-4065-A824-22897CD6EE00Q28217097-E62B2683-A130-49E4-A578-CF188CD6F463Q28254381-5040AD7F-907F-4115-9C84-2F5932E047A9Q28278834-A0AEF610-6C3F-4C1B-B34E-15625E9642FE
P2860
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@en
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@nl
type
label
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@en
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@nl
prefLabel
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@en
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@nl
P2093
P2860
P356
P1476
t(8;21) breakpoints on chromos ...... region of a single gene, AML1.
@en
P2093
P2860
P304
10431-10434
P356
10.1073/PNAS.88.23.10431
P407
P577
1991-12-01T00:00:00Z