Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.
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The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundaryUnderstanding DNA under oxidative stress and sensitization: the role of molecular modelingMolecular dynamics simulations of G-DNA and perspectives on the simulation of nucleic acid structuresThe exception that confirms the rule: a higher-order telomeric G-quadruplex structure more stable in sodium than in potassium.The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkagesCarbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-endSolution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?TMPyP4, a Stabilizer of Nucleic Acid Secondary Structure, Is a Novel Acetylcholinesterase InhibitorCobalt(III)porphyrin to target G-quadruplex DNA.Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD.Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Identification of novel quadruplex ligands from small molecule libraries by FRET-based high-throughput screening.Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separationTwo cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexesSynthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties."One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Making sense of G-quadruplex and i-motif functions in oncogene promoters.A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells.Advances in the molecular design of potential anticancer agents via targeting of human telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Effect of G-quadruplex polymorphism on the recognition of telomeric DNA by a metal complex.Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops.The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1.A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand.G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase.Recognition of chelerythrine to human telomeric DNA and RNA G-quadruplexes.Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach.A photoreactive G-quadruplex ligand triggered by green light.The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex.A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)2] and cis-[PtI2(NH3)2] compared for their reactivity towards DNA model systems.Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography.
P2860
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P2860
Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@en
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@nl
type
label
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@en
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@nl
prefLabel
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@en
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@nl
P1433
P1476
Human telomeric G-quadruplex: ...... eutic targets in human cancer.
@en
P2093
Stephen Neidle
P304
P356
10.1111/J.1742-4658.2009.07463.X
P407
P577
2009-11-27T00:00:00Z