The renewed potential for folate antagonists in contemporary cancer chemotherapy.
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Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probesDesign, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor AgentsDesign, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitorsStructure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductaseAn innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymes2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.Triazine-based condensing reagents.Maternal tea consumption during early pregnancy and the risk of spina bifidaSynthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis.Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1)Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates.Differentially correlated genes in co-expression networks control phenotype transitions.Antivitamins for Medicinal Applications.Rational drug design, synthesis and biological evaluation of dihydrofolate reductase inhibitors as antituberculosis agents.Molecular docking studies on DMDP derivatives as human DHFR inhibitors.Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting Tyrosine Kinases and Their Potential Anticancer Activities.
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P2860
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@en
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@nl
type
label
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@en
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@nl
prefLabel
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@en
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@nl
P356
P1476
The renewed potential for folate antagonists in contemporary cancer chemotherapy.
@en
P2093
P304
P356
10.1021/JM00106A001
P407
P577
1991-02-01T00:00:00Z