Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
about
An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymesIdentification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductaseThe design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting Tyrosine Kinases and Their Potential Anticancer Activities.Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan.
P2860
Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Design, synthesis, biological ...... drofolate reductase inhibitors
@ast
Design, synthesis, biological ...... drofolate reductase inhibitors
@en
Design, synthesis, biological ...... drofolate reductase inhibitors
@nl
type
label
Design, synthesis, biological ...... drofolate reductase inhibitors
@ast
Design, synthesis, biological ...... drofolate reductase inhibitors
@en
Design, synthesis, biological ...... drofolate reductase inhibitors
@nl
prefLabel
Design, synthesis, biological ...... drofolate reductase inhibitors
@ast
Design, synthesis, biological ...... drofolate reductase inhibitors
@en
Design, synthesis, biological ...... drofolate reductase inhibitors
@nl
P2093
P2860
P1476
Design, synthesis, biological ...... drofolate reductase inhibitors
@en
P2093
Aleem Gangjee
Jennifer Piraino
Roy L Kisliuk
Vivian Cody
Xilin Zhou
P2860
P304
P356
10.1016/J.BMC.2011.03.067
P407
P577
2011-06-01T00:00:00Z