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MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical managementMyc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogasterEvolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic MalignanciesA SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesisInhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiationDisruption of IFT complex A causes cystic kidneys without mitotic spindle misorientationThe enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivationInhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsCombinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy.Deciphering c-MYC-regulated genes in two distinct tissues.MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits.The Max b-HLH-LZ can transduce into cells and inhibit c-Myc transcriptional activities.Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis.Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisN-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cellsThe polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYCA critical role for Mnt in Myc-driven T-cell proliferation and oncogenesisDysregulation of RNA polymerase I transcription during disease.Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122.RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer.Targeting of the MYCN protein with small molecule c-MYC inhibitorscMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.Smad phosphoisoform signaling specificity: the right place at the right timePerturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in miceImportin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesisThe role of histone demethylase KDM4B in Myc signaling in neuroblastomaThe BCL-2 protein family, BH3-mimetics and cancer therapy.The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastomaThe BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs.Tissue-specific tumorigenesis: context matters.A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.Access to the nucleus and functional association with c-Myc is required for the full oncogenic potential of ΔEGFR/EGFRvIIICritical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis.Genetic Abnormalities in Biliary Brush Samples for Distinguishing Cholangiocarcinoma from Benign Strictures in Primary Sclerosing CholangitisBenzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish developmentKinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The ups and downs of Myc biology.
@en
The ups and downs of Myc biology.
@nl
type
label
The ups and downs of Myc biology.
@en
The ups and downs of Myc biology.
@nl
prefLabel
The ups and downs of Myc biology.
@en
The ups and downs of Myc biology.
@nl
P2860
P1476
The ups and downs of Myc biology.
@en
P2093
Gerard I Evan
P2860
P356
10.1016/J.GDE.2009.11.001
P50
P577
2009-12-03T00:00:00Z