Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
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Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination.Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminaseUracil DNA glycosylase interacts with the p32 subunit of the replication protein A complex to modulate HIV-1 reverse transcription for optimal virus dissemination.Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching.B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.
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Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Differential regulation of S-r ...... ions of uracil DNA glycosylase
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Differential regulation of S-r ...... ons of uracil DNA glycosylase.
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type
label
Differential regulation of S-r ...... ions of uracil DNA glycosylase
@en
Differential regulation of S-r ...... ons of uracil DNA glycosylase.
@nl
prefLabel
Differential regulation of S-r ...... ions of uracil DNA glycosylase
@en
Differential regulation of S-r ...... ons of uracil DNA glycosylase.
@nl
P2093
P2860
P356
P1476
Differential regulation of S-r ...... ions of uracil DNA glycosylase
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P2093
Andre Stanlie
Ashraf S Yousif
Nasim A Begum
Samiran Mondal
P2860
P304
P356
10.1073/PNAS.1402391111
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P50
P577
2014-03-03T00:00:00Z