Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe
about
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilitySomatic mutations in aging, cancer and neurodegenerationAntimutator variants of DNA polymerasesDefective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiaeIn vivo continuous directed evolutionReplicative DNA polymerase δ but not ε proofreads errors in Cis and in TransDNA replication error-induced extinction of diploid yeastThe evolution of genomic instability in the obligate endosymbionts of whitefliesNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantA cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.Efficient translesion replication in the absence of Escherichia coli Umu proteins and 3'-5' exonuclease proofreading function.Adaptive evolution of complex innovations through stepwise metabolic niche expansion.Optimization of DNA polymerase mutation rates during bacterial evolution.Evolution of evolvability.In vivo protein interactions within the Escherichia coli DNA polymerase III coreExamination of the role of DNA polymerase proofreading in the mutator effect of miscoding tRNAs.Genomes by design.The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae.The C-terminal domain of dnaQ contains the polymerase binding site.Comparative genome analysis of the pathogenic spirochetes Borrelia burgdorferi and Treponema pallidumMutator suppression and escape from replication error-induced extinction in yeastComposing life.A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutationsphi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein.Antimutator mutants in bacteriophage T4 and Escherichia coliGenetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Spontaneous frameshift mutations in Saccharomyces cerevisiae: accumulation during DNA replication and removal by proofreading and mismatch repair activities.Saturation of DNA mismatch repair and error catastrophe by a base analogue in Escherichia coli.Role of proofreading and mismatch repair in maintaining the stability of nucleotide repeats in DNA.Mutational analysis of the 3'-->5' proofreading exonuclease of Escherichia coli DNA polymerase IIIMutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase.dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity.Complete genetic linkage can subvert natural selection.Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex.Escherichia coli DnaE Polymerase Couples Pyrophosphatase Activity to DNA ReplicationDNA replication: one strand may be more equal.DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair.Stabilization of the Escherichia coli DNA polymerase III ε subunit by the θ subunit favors in vivo assembly of the Pol III catalytic core.
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P2860
Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutants in the Exo I motif of ...... ility due to error catastrophe
@en
Mutants in the Exo I motif of ...... lity due to error catastrophe.
@nl
type
label
Mutants in the Exo I motif of ...... ility due to error catastrophe
@en
Mutants in the Exo I motif of ...... lity due to error catastrophe.
@nl
prefLabel
Mutants in the Exo I motif of ...... ility due to error catastrophe
@en
Mutants in the Exo I motif of ...... lity due to error catastrophe.
@nl
P2860
P356
P1476
Mutants in the Exo I motif of ...... ility due to error catastrophe
@en
P2093
Fijalkowska IJ
Schaaper RM
P2860
P304
P356
10.1073/PNAS.93.7.2856
P407
P577
1996-04-01T00:00:00Z