Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.
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Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6Prediction of hepatic clearance in human from in vitro data for successful drug development.Covalent modification of proteins by cocaine.Quantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease.Hepatocellular uptake of sulfobromophthalein and bilirubin is selectively inhibited by an antibody to the liver plasma membrane sulfobromophthalein/bilirubin binding protein.Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gutUptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor.At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins.Models of hepatic drug elimination.Physiologically based liver modeling and risk assessment.Identification of albumin-binding proteins in capillary endothelial cellsIs there facilitated uptake of fatty acids by the liver? Interpretation and analysis of experimental data.Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake.Organic anion uptake by hepatocytes.Effect of microcirculatory heterogeneity on the determination of pharmacokinetic parameters: implications for risk assessment.Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.Measurement of blood-brain barrier permeability.An understanding of flow- and diffusion-limited vs. carrier-mediated hepatic transport: a simulation study.Facilitation of drug entry into brain by osmotic opening of the blood-brain barrier.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Hepatic oleate uptake. Electrochemical driving forces in intact rat liver.Membrane transport as a determinant of the hepatic elimination of drugs and metabolites.Uptake of thyroxine by the perfused rat liver: implications for the free hormone hypothesis.Stopped-flow kinetic analysis of long-chain fatty acid dissociation from bovine serum albumin.Availability predictions by hepatic elimination models for Michaelis-Menten kinetics.Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on evans blue, sucrose, water, and taurocholate.Kinetic analysis of the dose-dependent hepatic handling of 1-anilino-8-naphthalene sulfonate in rats.Bioreversible derivatives of phenol. 1. The role of human serum albumin as related to the stability and binding properties of carbonate esters with fatty acid-like structures in aqueous solution and biological media.Desorption kinetics of organic chemicals from albumin.Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: implications for neuroreceptor studies.The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.
P2860
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P2860
Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dissociation from albumin: a p ...... ce of substances by the liver.
@en
Dissociation from albumin: a p ...... ce of substances by the liver.
@nl
type
label
Dissociation from albumin: a p ...... ce of substances by the liver.
@en
Dissociation from albumin: a p ...... ce of substances by the liver.
@nl
prefLabel
Dissociation from albumin: a p ...... ce of substances by the liver.
@en
Dissociation from albumin: a p ...... ce of substances by the liver.
@nl
P2860
P356
P1476
Dissociation from albumin: a p ...... ce of substances by the liver.
@en
P2093
R A Weisiger
P2860
P304
P356
10.1073/PNAS.82.5.1563
P407
P577
1985-03-01T00:00:00Z