Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
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Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discriminationαβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapyLinking form to function: Biophysical aspects of artificial antigen presenting cell designStructural Model of the Extracellular Assembly of the TCR-CD3 Complex.Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor ActivityT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsA Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR DimerizationStructure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell ReceptorEvidence for a functional sidedness to the alphabetaTCR.Live cell imaging of protein dislocation from the endoplasmic reticulum.An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Organization of proximal signal initiation at the TCR:CD3 complex.Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.How the immune system talks to itself: the varied role of synapsesPiecing together the family portrait of TCR-CD3 complexes.T-cell growth, cell surface organization, and the galectin-glycoprotein lattice.Molecular architecture of the αβ T cell receptor-CD3 complex.Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.Change we can believe in--of the conformational type. Workshop on the Initiation of Antigen Receptor SignalingA conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.The alphabeta T cell receptor is an anisotropic mechanosensor.TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Codification of bidentate pMHC interaction with TCR and its co-receptor.The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins.The integration of signaling and the spatial organization of the T cell synapse.TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.Initiation of TCR phosphorylation and signal transduction.
P2860
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P2860
Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Solution structure of the CD3e ...... ceptor topology and signaling.
@en
Solution structure of the CD3e ...... ceptor topology and signaling.
@nl
type
label
Solution structure of the CD3e ...... ceptor topology and signaling.
@en
Solution structure of the CD3e ...... ceptor topology and signaling.
@nl
prefLabel
Solution structure of the CD3e ...... ceptor topology and signaling.
@en
Solution structure of the CD3e ...... ceptor topology and signaling.
@nl
P2093
P2860
P356
P1476
Solution structure of the CD3e ...... ceptor topology and signaling.
@en
P2093
Ellis L Reinherz
Gerhard Wagner
Il Chul Kim
Sun Taek Kim
Zhen-Yu J Sun
P2860
P304
16867-16872
P356
10.1073/PNAS.0407576101
P407
P577
2004-11-19T00:00:00Z