MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.
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The interplay of histone modifications - writers that readThe molecular mechanics of mixed lineage leukemia.The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5' End of SS-Overhang Cleavage.AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.Molecular mechanisms of MLL-associated leukemia.Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins.MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia.Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.The global cancer genomics consortium's symposium: new era of molecular medicine and epigenetic cancer medicine - cross section of genomics and epigenetics.Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
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MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@en
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@nl
type
label
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@en
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@nl
prefLabel
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@en
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@nl
P2093
P2860
P356
P1476
MLL fusion proteins link trans ...... sly active CpG-rich promoters.
@en
P2093
Akihiko Yokoyama
Akinori Kanai
Hiroshi Okuda
Hirotaka Matsui
Issay Kitabayashi
Marie Kawaguchi
Takeshi Kawamura
Toshiya Inaba
P2860
P304
P356
10.1093/NAR/GKT1394
P407
P577
2014-01-23T00:00:00Z