Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. - Wikidata - awgldk - TriplyDB

Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

http://www.wikidata.org/entity/Q37701743

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Focusing on shared subpockets - new developments in fragment-based drug discovery Efficient isocyanide-less isocyanide-based multicomponent reactions Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitor Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors.Multicomponent Reactions, Union of MCRs and Beyond.Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.Two-Step Synthesis of Complex Artificial Macrocyclic Compounds.Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists†.Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

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Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

http://www.wikidata.org/entity/Q37701743

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 January 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Discovery of highly potent p53 ...... e myeloid leukemia activities.

@en

Discovery of highly potent p53 ...... e myeloid leukemia activities.

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type

label

Discovery of highly potent p53 ...... e myeloid leukemia activities.

@en

Discovery of highly potent p53 ...... e myeloid leukemia activities.

@nl

prefLabel

Discovery of highly potent p53 ...... e myeloid leukemia activities.

@en

Discovery of highly potent p53 ...... e myeloid leukemia activities.

@nl

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ACS Chemical Biology

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Discovery of highly potent p53 ...... te myeloid leukemia activities

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Aleksandra Twarda

http://www.w3.org/2001/XMLSchema#string

Barbara Beck

http://www.w3.org/2001/XMLSchema#string

Grzegorz M Popowicz

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Kareem Khoury

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Lisa-Maria Köhler

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Marion Subklewe

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Sayed K Goda

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Siglinde Wolf

http://www.w3.org/2001/XMLSchema#string

Tad A Holak

http://www.w3.org/2001/XMLSchema#string

Yijun Huang

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists

Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists

Discovering high-affinity ligands for proteins: SAR by NMR

Multicomponent Reactions with Isocyanides.

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists

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802-811

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scholarly article

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10.1021/CB400728E

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3

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9

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2014-01-17T00:00:00Z

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24405416

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