The regulatory crosstalk between kinases and proteases in cancer.
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ADAMTS-12 metalloprotease is necessary for normal inflammatory responseLoss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in miceSmart nanosystems: Bio-inspired technologies that interact with the host environmentReceptor tyrosine kinases in the nucleusProtease signalling: the cutting edgeA membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cellsPhosphorylation regulates assembly of the caspase-6 substrate-binding groove.TrxR1 as a potent regulator of the Nrf2-Keap1 response systemIntegrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapyBasic principles and emerging concepts in the redox control of transcription factorsUbiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1Network analyses reveal pervasive functional regulation between proteases in the human protease webThe coming of age of phosphoproteomics--from large data sets to inference of protein functionsThe KLK5 protease suppresses breast cancer by repressing the mevalonate pathwayNetwork target for screening synergistic drug combinations with application to traditional Chinese medicineNon-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesisProteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating PSA activityPericellular proteolysis in cancerSLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination.A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin SSystematic analysis of the in situ crosstalk of tyrosine modifications reveals no additional natural selection on multiply modified residues.PEAK1, a novel kinase target in the fight against cancer.Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptaseAnalysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.Comparative genome analysis of Prevotella intermedia strain isolated from infected root canal reveals features related to pathogenicity and adaptation.The functional and pathologic relevance of autophagy proteases.Regulation by S-nitrosylation of protein post-translational modification.Protease-activated drug development.Charting Immune Signaling Proteomes En Route to New Therapeutic Strategies.Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.Molecular targeted approaches for treatment of pancreatic cancer.USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.PH motifs in PAR1&2 endow breast cancer growth.Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion.New approaches for dissecting protease functions to improve probe development and drug discoveryA quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations.
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The regulatory crosstalk between kinases and proteases in cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 March 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The regulatory crosstalk between kinases and proteases in cancer.
@en
The regulatory crosstalk between kinases and proteases in cancer.
@nl
type
label
The regulatory crosstalk between kinases and proteases in cancer.
@en
The regulatory crosstalk between kinases and proteases in cancer.
@nl
prefLabel
The regulatory crosstalk between kinases and proteases in cancer.
@en
The regulatory crosstalk between kinases and proteases in cancer.
@nl
P356
P1476
The regulatory crosstalk between kinases and proteases in cancer.
@en
P2093
Tony Hunter
P2888
P304
P356
10.1038/NRC2823
P407
P577
2010-03-19T00:00:00Z