The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
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The hitchhiker's guide to the voltage-gated sodium channel galaxyConotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel InhibitionTetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical UsesComputational studies of marine toxins targeting ion channelsSelective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspectsConvergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis.Is there more than one way to skin a newt? Convergent toxin resistance in snakes is not due to a common genetic mechanism.Evolutionary history of a complex adaptation: tetrodotoxin resistance in salamanders.Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesMolecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.Tetrodotoxin (TTX) as a therapeutic agent for pain.Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels.Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomesA voltage-gated sodium channel is essential for the positive selection of CD4(+) T cellsAnimal toxins can alter the function of Nav1.8 and Nav1.9.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers.Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.Dynamical characterization of inactivation path in voltage-gated Na(+) ion channel by non-equilibrium response spectroscopy.Recent progress in neuroactive marine natural products.Behavioral and chemical ecology of marine organisms with respect to tetrodotoxin.Advances in targeting voltage-gated sodium channels with small molecules.The chemistry and biology of organic guanidine derivatives.Animal toxins influence voltage-gated sodium channel function.Saxitoxin.Voltage-gated sodium channels in the mammalian heart.Action potentials in primary osteoblasts and in the MG-63 osteoblast-like cell line.Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.Tetrodotoxin blockade on canine cardiac L-type Ca²⁺ channels depends on pH and redox potential.An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids.Development and single laboratory validation of an optical biosensor assay for tetrodotoxin detection as a tool to combat emerging risks in European seafood.Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.Differential Effects of Inactivation of Discrete Regions of Medial Prefrontal Cortex on Memory Consolidation of Moderate and Intense Inhibitory Avoidance Training.Large-effect mutations generate trade-off between predatory and locomotor ability during arms race coevolution with deadly preyPredicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
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The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@en
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@nl
type
label
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@en
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@nl
prefLabel
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@en
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@nl
P2860
P356
P1433
P1476
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
@en
P2093
Gregory M Lipkind
Harry A Fozzard
P2860
P304
P356
10.3390/MD8020219
P577
2010-02-01T00:00:00Z