Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?
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IgG4 Characteristics and Functions in Cancer ImmunitySelective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor InteractionsStructure and specificity of an antibody targeting a proteolytically cleaved IgG hingeIron and zinc exploitation during bacterial pathogenesisGlycan analysis of therapeutic glycoproteinsLeporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domainsMIB-MIP is a mycoplasma system that captures and cleaves immunoglobulin GMicrobially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2Computational analyses of an evolutionary arms race between mammalian immunity mediated by immunoglobulin A and its subversion by bacterial pathogens.IgG subclasses and allotypes: from structure to effector functions.Anti-Hinge Antibodies Recognize IgG Subclass- and Protease-Restricted Neoepitopes.Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3).Bacillus anthracis Overcomes an Amino Acid Auxotrophy by Cleaving Host Serum ProteinsRelationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.Cross-reactive and pre-existing antibodies to therapeutic antibodies--Effects on treatment and immunogenicity.Antibody-Based Biologics and Their Promise to Combat Staphylococcus aureus Infections.A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.The role for neutrophil extracellular traps in cystic fibrosis autoimmunity.Nivolumab dose selection: challenges, opportunities, and lessons learned for cancer immunotherapyBacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor.Delivery of Flightless I Neutralizing Antibody from Porous Silicon Nanoparticles Improves Wound Healing in Diabetic Mice.Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis.Specificity of human anti-variable heavy (VH ) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor-α receptor 1.A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo.Association of time-varying clearance of nivolumab with disease dynamics and its implications on exposure response analysis.Accumulation of secreted antibodies in plant cell cultures varies according to the isotype, host species and culture conditions.Engineered protease-resistant antibodies with selectable cell-killing functions.Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity.The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge.Evading pre-existing anti-hinge antibody binding by hinge engineering.Preexisting Antibodies to an F(ab')2 Antibody Therapeutic and Novel Method for Immunogenicity Assessment.Rapid IgG heavy chain cleavage by the streptococcal IgG endopeptidase IdeS is mediated by IdeS monomers and is not due to enzyme dimerization.Molecular characterization of human anti-hinge antibodies derived from single cell cloning of normal human B cells.Characterization of aromatic residue-controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae.Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS.
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Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 May 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cleavage of IgGs by proteases ...... tactic against host immunity?
@en
Cleavage of IgGs by proteases ...... tactic against host immunity?
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type
label
Cleavage of IgGs by proteases ...... tactic against host immunity?
@en
Cleavage of IgGs by proteases ...... tactic against host immunity?
@nl
prefLabel
Cleavage of IgGs by proteases ...... tactic against host immunity?
@en
Cleavage of IgGs by proteases ...... tactic against host immunity?
@nl
P2860
P356
P1476
Cleavage of IgGs by proteases ...... tactic against host immunity?
@en
P2093
Robert E Jordan
P2860
P304
P356
10.4161/MABS.2.3.11780
P577
2010-05-23T00:00:00Z