Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease.
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Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer modelThe toxicity of amyloid β oligomersImpairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story?Vitamin Supplementation as an Adjuvant Treatment for Alzheimer's DiseaseAmyloid-β oligomers are sequestered by both intracellular and extracellular chaperonesOral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model.Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive declinePyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase.Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids.Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypesSynapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector.Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disordersMitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's diseaseThe β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Early-onset dysfunction of retrosplenial cortex precedes overt amyloid plaque formation in Tg2576 mice.Sequence-dependent internalization of aggregating peptidesNuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's diseaseHerpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulationSynaptic activity and Alzheimer's disease: a critical update.Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in CellsAmyloidosis in Alzheimer's Disease: The Toxicity of Amyloid Beta (A β ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for TherapyN-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody.Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer's DiseaseAbundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.Insights into Alzheimer disease pathogenesis from studies in transgenic animal models.Contribution of yeast models to neurodegeneration research.Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases.Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression.Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.The fourth element targeting hypothesis of Alzheimer's disease pathogenesis and pathophysiology.
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Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 March 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Intracellular accumulation of ...... n loss in Alzheimer's disease.
@en
Intracellular accumulation of ...... n loss in Alzheimer's disease.
@nl
type
label
Intracellular accumulation of ...... n loss in Alzheimer's disease.
@en
Intracellular accumulation of ...... n loss in Alzheimer's disease.
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prefLabel
Intracellular accumulation of ...... n loss in Alzheimer's disease.
@en
Intracellular accumulation of ...... n loss in Alzheimer's disease.
@nl
P2860
P356
P1476
Intracellular accumulation of ...... n loss in Alzheimer's disease.
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P2093
Oliver Wirths
Thomas A Bayer
P2860
P356
10.3389/FNAGI.2010.00008
P577
2010-03-10T00:00:00Z