Still embedded together binding to membranes regulates Bcl-2 protein interactions.
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tBid undergoes multiple conformational changes at the membrane required for Bax activationMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsA yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisThe anti-apoptotic Bcl-x(L) protein, a new piece in the puzzle of cytochrome c interactomeA strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphomaDirect Activation of Bax Protein for Cancer TherapyPushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAXUltra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.The use of therapeutic peptides to target and to kill cancer cells.Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xLCellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway.The rheostat in the membrane: BCL-2 family proteins and apoptosisProgramming biological models in Python using PySBBH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.Transformations of the macromolecular landscape at mitochondria during DNA-damage-induced apoptotic cell death.Bax forms two types of channels, one of which is voltage-gatedSynergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis.PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.Mitochondria and apoptosis: emerging concepts.Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric speciesWogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells.Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis.Mesenchymal stem cells preconditioned with trimetazidine promote neovascularization of hearts under hypoxia/reoxygenation injury.Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.Mechanisms of action of Bcl-2 family proteinsPhysiological restraint of Bak by Bcl-xL is essential for cell survival.Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosisBax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes.Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survivalAfter embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.Apoptosis: why and how does it occur in biology?Multipolar functions of BCL-2 proteins link energetics to apoptosisThe secrets of the Bcl-2 family.Biomarkers of therapeutic response to BCL2 antagonists in cancer.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.
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Still embedded together binding to membranes regulates Bcl-2 protein interactions.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 19 July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Still embedded together binding to membranes regulates Bcl-2 protein interactions.
@en
Still embedded together binding to membranes regulates Bcl-2 protein interactions.
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type
label
Still embedded together binding to membranes regulates Bcl-2 protein interactions.
@en
Still embedded together binding to membranes regulates Bcl-2 protein interactions.
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Still embedded together binding to membranes regulates Bcl-2 protein interactions.
@en
Still embedded together binding to membranes regulates Bcl-2 protein interactions.
@nl
P356
P1433
P1476
Still embedded together binding to membranes regulates Bcl-2 protein interactions
@en
P2093
P2888
P304
P356
10.1038/ONC.2010.283
P407
P577
2010-07-19T00:00:00Z