BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
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Regulation of Bim in Health and DiseaseEfficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapyAspirin delimits platelet life span by proteasomal inhibitionMegakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistagesBacteria differentially induce degradation of Bcl-xL, a survival protein, by human plateletsRegulatory role of proteasome in determination of platelet life spanThe role of apoptosis in megakaryocytes and platelets.Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and ThrombocytopeniaInvestigation of platelet function and platelet disorders using flow cytometry.Regulation of platelet lifespan by apoptosis.Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.Regulation of platelet membrane protein shedding in health and disease.Non-apoptotic functions of caspases in myeloid cell differentiation.Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.Mechanistic insight of platelet apoptosis leading to non-surgical bleeding among heart failure patients supported by continuous-flow left ventricular assist devices.Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis.Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced deathDual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists.Expression of FGF4 mRNA is mediated by mating behaviours in mice.Bcl-xL/Bak interaction and regulation by miRNA let-7b in the intrinsic apoptotic pathway of stored platelets.Protein kinase A determines platelet life span and survival by regulating apoptosis.Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis.P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.Mechanisms of platelet clearance and translation to improve platelet storage.MCL-1 inhibition in cancer treatment
P2860
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P2860
BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@ast
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@en
type
label
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@ast
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@en
prefLabel
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@ast
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@en
P2093
P2860
P356
P1476
BH3-only activator proteins Bi ...... way to apoptosis in platelets.
@en
P2093
Atsushi Hosui
Hayato Hikita
Hisashi Ishida
Minoru Shigekawa
Naoki Hiramatsu
Norio Hayashi
Satoshi Shimizu
Takuya Miyagi
Tatsuya Kanto
Tetsuo Takehara
P2860
P304
13905-13913
P356
10.1074/JBC.M110.195370
P407
P577
2011-03-02T00:00:00Z