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HIF hydroxylase pathways in cardiovascular physiology and medicineHIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progressionIron, oxygen, and the pulmonary circulationGenetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateauThe role of PHD2 mutations in the pathogenesis of erythrocytosis.HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.Genetic signatures of high-altitude adaptation in TibetansDefective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensingThe physiological functions of iron regulatory proteins in iron homeostasis - an update.HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolismHuman high-altitude adaptation: forward genetics meets the HIF pathway.Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness.Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.Anaemia in kidney disease: harnessing hypoxia responses for therapyTwo new mutations in the HIF2A gene associated with erythrocytosis.Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.Treatment of erythropoietin deficiency in mice with systemically administered siRNA.A non-synonymous SNP with the allele frequency correlated with the altitude may contribute to the hypoxia adaptation of Tibetan chickenMethemoglobinemia and ascorbate deficiency in hemoglobin E β thalassemia: metabolic and clinical implications.New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain SicknessConditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorptionGlucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathwayFirst report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome.The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W).The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutationCITED2 modulation of trophoblast cell differentiation: insights from global transcriptome analysis.Regulation of erythropoiesis by hypoxia-inducible factorsCongenital erythrocytosis associated with gain-of-function HIF2A gene mutations and erythropoietin levels in the normal range.The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cellsA knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.Prolyl 4-hydroxylases, master regulators of the hypoxia response.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The HIF pathway and erythrocytosis.
@en
The HIF pathway and erythrocytosis.
@nl
type
label
The HIF pathway and erythrocytosis.
@en
The HIF pathway and erythrocytosis.
@nl
prefLabel
The HIF pathway and erythrocytosis.
@en
The HIF pathway and erythrocytosis.
@nl
P1476
The HIF pathway and erythrocytosis.
@en
P2093
Frank S Lee
Melanie J Percy
P304
P356
10.1146/ANNUREV-PATHOL-011110-130321
P577
2011-01-01T00:00:00Z