Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
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Mutant p53: Multiple Mechanisms Define Biologic Activity in CancerAnother fork in the road--life or death decisions by the tumour suppressor p53p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Characterization of a new mouse p53 variant: loss-of-function and gain-of-function.Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.Tissue-specific and age-dependent effects of global Mdm2 lossLow levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.MDM2, MDMX and p53 in oncogenesis and cancer therapyIntegrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21-Mediated Early Senescence SignallingUsing targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival.Minireview: animal models and mechanisms of ovarian cancer development.Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responsesSpecific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Prolonged expression of senescence markers in mice exposed to gamma-irradiation.Impaired mitochondrial metabolism and mammary carcinogenesisA threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.Apoptosis status and proliferative activity in mucopolysaccharidosis type I mice tongue mucosa cells.Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila.Distal airway epithelial progenitor cells are radiosensitive to High-LET radiationCancer biology and genomics: translating discoveries, transforming pathology.Transcriptional modulation induced by ionizing radiation: p53 remains a central player.Ionizing radiation induces neuronal differentiation of Neuro-2a cells via PI3-kinase and p53-dependent pathways.Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence.High Ki67 expression is an independent good prognostic marker in colorectal cancer.Defective cell cycle checkpoints as targets for anti-cancer therapies.Global re-wiring of p53 transcription regulation by the hepatitis B virus X proteinIdentification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes.The chemosensitivity of testicular germ cell tumors.
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P2860
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@en
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@nl
type
label
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@en
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@nl
prefLabel
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@en
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
@nl
P2860
P356
P1476
Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo
@en
P2093
Guillermina Lozano
Sean M Post
P2860
P304
P356
10.1002/PATH.2783
P577
2010-10-18T00:00:00Z