Cutting the nonsense: the degradation of PTC-containing mRNAs.
about
Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosisAgo2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2RNA around the clock - regulation at the RNA level in biological timingThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Organizing principles of mammalian nonsense-mediated mRNA decayA lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assaysThe RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNAApproaches to Fungal Genome AnnotationFunctional characterisation of human cells harbouring a novel t(2p;7p) translocation involving TNS3 and EXOC6B genesNovel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation.A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Unspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cellsThe interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.Towards understanding the low prevalence of Helicobacter pylori in Malays: genetic variants among Helicobacter pylori-negative ethnic Malays in the north-eastern region of Peninsular Malaysia and Han Chinese and South Indians.Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis.Nonsense-mediated mRNA decay controls the changes in yeast ribosomal protein pre-mRNAs levels upon osmotic stressTranscriptional and post-transcriptional regulation of the jasmonate signalling pathway in response to abiotic and harvesting stress in Hevea brasiliensis.Method for quantitative analysis of nonsense-mediated mRNA decay at the single cell levelNovel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.Imaging of endogenous messenger RNA splice variants in living cells reveals nuclear retention of transcripts inaccessible to nonsense-mediated decay in Arabidopsis.Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.A highly conserved region essential for NMD in the Upf2 N-terminal domainIntronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma and leukosis virus subgroup A.A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translationThe multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities.Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroup A.Regulation of cytoplasmic mRNA decay.Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention.A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function.Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response.Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nucleaseAPPRIS: annotation of principal and alternative splice isoforms.SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay.Degradation of mRNAs that lack a stop codon: a decade of nonstop progressXRN 5'→3' exoribonucleases: structure, mechanisms and functions.NMD: a multifaceted response to premature translational termination.The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development.Regulation of nonsense-mediated mRNA decay.
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P2860
Cutting the nonsense: the degradation of PTC-containing mRNAs.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@en
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@nl
type
label
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@en
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@nl
prefLabel
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@en
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@nl
P356
P1476
Cutting the nonsense: the degradation of PTC-containing mRNAs.
@en
P2093
Pamela Nicholson
P304
P356
10.1042/BST0381615
P577
2010-12-01T00:00:00Z