GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.
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Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)A double-edged sword: volatile anesthetic effects on the neonatal brain.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.How theories evolved concerning the mechanism of action of barbiturates.Etifoxine for pain patients with anxiety.Comparison of subarachnoid anesthetic effect of emulsified volatile anesthetics in rats.Propofol effectively inhibits lithium-pilocarpine- induced status epilepticus in rats via downregulation of N-methyl-D-aspartate receptor 2B subunit expressionMmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.Altered GABA signaling in early life epilepsies.Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.Neurodevelopmental implications of the general anesthesia in neonate and infants.Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study.Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domainEffect of (+)-dehydrofukinone on GABAA receptors and stress response in fish modelRegulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide.Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.Plant-derived extracts in the neuroscience of anxiety on animal models: biases and comments.A novel GABA(A) receptor pharmacology: drugs interacting with the α(+) β(-) interface.Sedation for critically ill or injured adults in the intensive care unit: a shifting paradigm.Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA Receptor Currents.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.Local anaesthetic refinement of pentobarbital euthanasia reduces abdominal writhing without affecting immunohistochemical endpoints in rats.Explaining general anesthesia: a two-step hypothesis linking sleep circuits and the synaptic release machinery.Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity.Analysis of γ-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands.GABAA receptor: Positive and negative allosteric modulators.Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects.
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GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 December 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
GABA(A) receptors as molecular ...... lues to allosteric modulation.
@en
type
label
GABA(A) receptors as molecular ...... lues to allosteric modulation.
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prefLabel
GABA(A) receptors as molecular ...... lues to allosteric modulation.
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P2860
P921
P1476
GABA(A) receptors as molecular ...... lues to allosteric modulation.
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P2093
Guo-Dong Li
Richard W Olsen
P2860
P2888
P304
P356
10.1007/S12630-010-9429-7
P577
2010-12-31T00:00:00Z
2011-02-01T00:00:00Z