Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases.
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Cellular targeting in autoimmunityInflammation and vascular injury: basic discovery to drug developmentSmall molecules in the treatment of systemic lupus erythematosusSyk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas.Critical role for Syk in responses to vascular injury.Systematic assessment of multi-gene predictors of pan-cancer cell line sensitivity to drugs exploiting gene expression data.Quinoxaline derivatives: a patent review (2006--present).Novel small molecule therapeutics in rheumatoid arthritis.Molecular abnormalities of the B cell in systemic lupus erythematosus are candidates for functional inhibition treatments.VHR/DUSP3 phosphatase: structure, function and regulation.PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy VolunteersQuantification of "end products" of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways -- implications for modern clinical chemistry.Development of a pharmacodynamic assay based on PLCγ2 phosphorylation for quantifying spleen tyrosine kinase (SYK)-Bruton's tyrosine kinase (BTK) signaling.The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.Characterization of the disposition of fostamatinib in Japanese subjects including pharmacokinetic assessment in dry blood spots: results from two phase I clinical studies.The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis.Inhibition of spleen tyrosine kinase as treatment of postoperative ileus.Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury.Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury
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Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 December 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
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Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
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type
label
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
@en
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
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prefLabel
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
@en
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
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P2860
P921
P356
P1476
Spleen tyrosine kinase inhibit ...... and autoinflammatory diseases.
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P2093
George C Tsokos
Omer N Pamuk
P2860
P2888
P356
10.1186/AR3198
P577
2010-12-17T00:00:00Z
P5875
P6179
1045688844