Helix-mediated protein--protein interactions as targets for intervention using foldamers.
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Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic designEnhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain ArrayExploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologiesModeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsDesign of libraries targeting protein-protein interfaces.Assessing helical protein interfaces for inhibitor design.New Frontiers in DruggabilityEnd-Capped α-Helices as Modulators of Protein FunctionStructural Divergence of the Group I Intron Binding Surface in Fungal Mitochondrial Tyrosyl-tRNA Synthetases That Function in RNA Splicing.Stabilized helical peptides: overview of the technologies and therapeutic promises.Tunable Helicity, Stability and DNA-Binding Properties of Short Peptides with Hybrid Metal Coordination Motifs.Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.Developing a PPI inhibitor-based therapy for STXBP1 haploinsufficiency-associated epileptic disorders.Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03559c Click here for additional data file.Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers.Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors.2-O-alkylated para-benzamide α-helix mimetics: the role of scaffold curvature.Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane.Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53-hDM2 Protein-Protein InteractionHomooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigationEvolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery
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Helix-mediated protein--protein interactions as targets for intervention using foldamers.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 March 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en-gb
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
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type
label
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en-gb
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@nl
prefLabel
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en-gb
Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@nl
P2860
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Helix-mediated protein--protein interactions as targets for intervention using foldamers.
@en
P2093
Andrew J Wilson
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P2888
P304
P356
10.1007/S00726-011-0880-8
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2011-03-17T00:00:00Z