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Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeletonThe emerging roles of ribosome biogenesis in craniofacial developmentp21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 PathwayPak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiationDownregulation of microRNA-23a suppresses prostate cancer metastasis by targeting the PAK6-LIMK1 signaling pathwayPAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesisSmall molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.p21-Activated kinase inhibitors: a patent reviewTranscriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesisSignaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells.Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite.Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration.Entamoeba histolytica RacC selectively engages p21-activated kinase effectorsOverexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.Function of cancer associated genes revealed by modern univariate and multivariate association tests.Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 InhibitorInhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.GIT2 deficiency attenuates concanavalin A-induced hepatitis in miceCrosstalk between casein kinase II and Ste20-related kinase Nak1.Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?Recent advances in the development of p21-activated kinase inhibitorsSmall Rho GTPases in the control of cell shape and mobility.p21-Activated protein kinases and their emerging roles in glucose homeostasis.Clinicopathological and cellular signature of PAK1 in human bladder cancer.P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma.Depletion of PAK1 enhances ubiquitin-mediated survivin degradation in pancreatic β-cells.Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens.The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.PAK1: A Therapeutic Target for Cancer TreatmentH2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemiaRac1 in the driver’s seat for melanomaPak2 regulates myeloid-derived suppressor cell development in mice
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
p21-activated kinase 1: PAK'ed with potential.
@en
p21-activated kinase 1: PAK'ed with potential.
@nl
type
label
p21-activated kinase 1: PAK'ed with potential.
@en
p21-activated kinase 1: PAK'ed with potential.
@nl
prefLabel
p21-activated kinase 1: PAK'ed with potential.
@en
p21-activated kinase 1: PAK'ed with potential.
@nl
P2093
P2860
P921
P356
P1433
P1476
p21-activated kinase 1: PAK'ed with potential.
@en
P2093
Adrian M Jubb
Christy C Ong
Hartmut Koeppen
Klaus P Hoeflich
Lori S Friedman
Marcia Belvin
Peter M Haverty
P2860
P304
P356
10.18632/ONCOTARGET.271
P407
P5008
P577
2011-06-01T00:00:00Z