The IgH locus 3' regulatory region: pulling the strings from behind.
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Long-Range Regulation of V(D)J RecombinationRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationThe IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesisAID and Apobec3G haphazard deamination and mutational diversityElucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.AID-induced remodeling of immunoglobulin genes and B cell fate.Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA contextHS1,2 Ig enhancer alleles association to AIDS progression in a pediatric cohort infected with a monophyletic HIV-strainA novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutationSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma.The change in Ig regulation from children to adults disconnects the correlation with the 3'RR hs1.2 polymorphism.Targeting the oncogene B lymphoma deregulator IgH 3' regulatory region does not impede the in vivo inflammatory response in mice.CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.The aryl hydrocarbon receptor regulates an essential transcriptional element in the immunoglobulin heavy chain gene.RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombination.Enhancers located in heavy chain regulatory region (hs3a, hs1,2, hs3b, and hs4) are dispensable for diversity of VDJ recombinationMouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulationDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory regionThe IgH 3' regulatory region controls somatic hypermutation in germinal center B cellsPolyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombinationThe AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region.Role of the Igh intronic enhancer Eμ in clonal selection at the pre-B to immature B cell transition.Genomic Architecture may Influence Recurrent Chromosomal Translocation Frequency in the Igh Locus.The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Mechanisms of programmed DNA lesions and genomic instability in the immune system.Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Class-Switch Recombination in the Absence of the IgH 3' Regulatory Region.RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line.AID-driven deletion causes immunoglobulin heavy chain locus suicide recombination in B cells.The role of CTCF binding sites in the 3' immunoglobulin heavy chain regulatory region.Erroneous class switching and false VDJ recombination: molecular dissection of t(8;14)/MYC-IGH translocations in Burkitt-type lymphoblastic leukemia/B-cell lymphoma.CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination.Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.The IgH 3' regulatory region influences lymphomagenesis in Igλ-Myc mice
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P2860
The IgH locus 3' regulatory region: pulling the strings from behind.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on January 2011
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The IgH locus 3' regulatory region: pulling the strings from behind.
@en
The IgH locus 3' regulatory region: pulling the strings from behind.
@nl
type
label
The IgH locus 3' regulatory region: pulling the strings from behind.
@en
The IgH locus 3' regulatory region: pulling the strings from behind.
@nl
prefLabel
The IgH locus 3' regulatory region: pulling the strings from behind.
@en
The IgH locus 3' regulatory region: pulling the strings from behind.
@nl
P2093
P1476
The IgH locus 3' regulatory region: pulling the strings from behind.
@en
P2093
Christelle Vincent-Fabert
Eric Pinaud
Marie Marquet
Michel Cogné
Rémi Fiancette
Sophie Péron
Yves Denizot
P356
10.1016/B978-0-12-387663-8.00002-8
P577
2011-01-01T00:00:00Z