The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
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Long-Range Regulation of V(D)J RecombinationRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationThe IgH 3' regulatory region and c-myc-induced B-cell lymphomagenesisA Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.AID-induced remodeling of immunoglobulin genes and B cell fate.Eμ and 3'RR IgH enhancers show hierarchic unilateral dependence in mature B-cells.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA contextUracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma.The change in Ig regulation from children to adults disconnects the correlation with the 3'RR hs1.2 polymorphism.AID-initiated DNA lesions are differentially processed in distinct B cell populations.The class-specific BCR tonic signal modulates lymphomagenesis in a c-myc deregulation transgenic model.Targeting the oncogene B lymphoma deregulator IgH 3' regulatory region does not impede the in vivo inflammatory response in mice.Overlapping hotspots in CDRs are critical sites for V region diversificationTargeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genesAntibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesDeciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region.Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory regionThe IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody GenesClass-Switch Recombination in the Absence of the IgH 3' Regulatory Region.RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.The IgH 3' regulatory region influences lymphomagenesis in Igλ-Myc miceEfficient role of IgH 3' regulatory region deficient B-cells in the development of oil granulomas.The IgH 3' regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate.Pre-germinal center origin for mature mouse B cell lymphomas: a major discrepancy with human mature lymphomas.A new 3'RR regulatory role during lymphomagenesis.3'RR targeting in lymphomagenesis: a promising strategy?Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch recombination.Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.[The IgH 3'RR: Doctor Jekyll and Mister Hyde of B-cell maturation and lymphomagenesis].The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombinationand isoforms are both efficient to drive B cell differentiation3' enhancers hs3b/hs4 are dispensable for deregulation in mouse plasmacytomas with T(12;15) translocations
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
@en
The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.
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The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
@en
The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells.
@nl
P2093
P2860
P50
P356
P1476
The IgH 3' regulatory region controls somatic hypermutation in germinal center B cells
@en
P2093
Alexis Saintamand
Christelle Vincent-Fabert
Isabelle Robert
Marie Marquet
Rémi Fiancette
Yves Denizot
P2860
P304
P356
10.1084/JEM.20130072
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P577
2013-07-01T00:00:00Z