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Sirtuin functions and modulation: from chemistry to the clinicIn Search of New Therapeutic Targets in Obesity Treatment: SirtuinsRedox regulation of SIRT1 in inflammation and cellular senescenceModulation of tumorigenesis by dietary intervention is not mediated by SIRT1 catalytic activitySirtuins and nonalcoholic fatty liver diseaseAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemResveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-RegulationInterplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.The Synergistic Role of Light-Feeding Phase Relations on Entraining Robust Circadian Rhythms in the Periphery.A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer CellsSirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approachesBlocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.Resveratrol in metabolic health: an overview of the current evidence and perspectives.Epigenetic drugs against cancer: an evolving landscape.Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in miceDysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice.Sirtuins, aging, and cardiovascular risks.Novel sirtuin inhibitory warheads derived from the N(ε)-acetyl-lysine analog L-2-amino-7-carboxamidoheptanoic acid.Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal FibrogenesisSystemic regulation of mammalian ageing and longevity by brain sirtuins.Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 InhibitorThe influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice.SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease.Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents.Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell deathAlterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats.Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway.Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1.Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding.SIRT3 Expression Decreases with Reactive Oxygen Species Generation in Rat Cortical Neurons during Early Brain Injury Induced by Experimental Subarachnoid Hemorrhage.Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.Small molecule SIRT1 activators for the treatment of aging and age-related diseases.Sirtuins and Their Roles in Brain Aging and Neurodegenerative DisordersModulators of HIF1α and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression?Nutrition and health during mid-life: searching for solutions and meeting challenges for the aging population.
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Sirtuin activators and inhibitors.
@en
type
label
Sirtuin activators and inhibitors.
@en
prefLabel
Sirtuin activators and inhibitors.
@en
P2860
P356
P1433
P1476
Sirtuin activators and inhibitors.
@en
P2093
Francisco J Alcaín
José M Villalba
P2860
P304
P356
10.1002/BIOF.1032
P577
2012-06-25T00:00:00Z