The biological activity of auranofin: implications for novel treatment of diseases.
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Cardiovascular and Hepatic Toxicity of Cocaine: Potential Beneficial Effects of Modulators of Oxidative StressA conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareA new look at auranofin, dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseasesAuranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53Gold(I)-triphenylphosphine complexes with hypoxanthine-derived ligands: in vitro evaluations of anticancer and anti-inflammatory activitiesRepurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasisGold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agentsMycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant DefenseAuranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasisAllosteric cross-talk in chromatin can mediate drug-drug synergy.Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strainsNanotechnology in radiation oncology.Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthCUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancerNovel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cellsAuranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling PathwayAuranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections.Auranofin is a potent suppressor of osteosarcoma metastasis.Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells.X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.Novel action and mechanism of auranofin in inhibition of vascular endothelial growth factor receptor-3-dependent lymphangiogenesis.Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.Osteoarthritis of the hand II: chemistry, pharmacokinetics and pharmacodynamics of naproxen, and clinical outcome studies.Benzyl-substituted metallocarbene antibiotics and anticancer drugs.The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells.Oxidative stress and proteasome inhibitors in multiple myeloma.Novel antitumor adamantane-azole gold(I) complexes as potential inhibitors of thioredoxin reductase.Selective inhibitory effects of 50-nm gold nanoparticles on mouse macrophage and spleen cells.Selection and characterization of a human ovarian cancer cell line resistant to auranofin.Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study.Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing.Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity.Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections.Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr)In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria
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The biological activity of auranofin: implications for novel treatment of diseases.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
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name
The biological activity of auranofin: implications for novel treatment of diseases.
@en
type
label
The biological activity of auranofin: implications for novel treatment of diseases.
@en
prefLabel
The biological activity of auranofin: implications for novel treatment of diseases.
@en
P2093
P2860
P1433
P1476
The biological activity of auranofin: implications for novel treatment of diseases.
@en
P2093
A Klegeris
D L Gibson
J M Madeira
P2860
P2888
P304
P356
10.1007/S10787-012-0149-1
P577
2012-09-11T00:00:00Z