A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling. - Wikidata - awgldk - TriplyDB

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

http://www.wikidata.org/entity/Q38044445

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Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy Emerging preclinical pharmacological targets for Parkinson's disease The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease Two-Pore Channels: Lessons from Mutant Mouse Models The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.Targeting leucine-rich repeat kinase 2 in Parkinson's disease.The role of Ca2+ signaling in Parkinson's disease.Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.

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P2860

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

http://www.wikidata.org/entity/Q38044445

description

article científic

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article scientifique

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artikel ilmiah

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name

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

@en

type

label

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

@en

prefLabel

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

@en

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P1433

Biochemical Society Transactions

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A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

@en

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Grant C Churchill

http://www.w3.org/2001/XMLSchema#string

Patricia Gómez-Suaga

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P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

NAADP mobilizes calcium from acidic organelles through two-pore channels

P304

1140-1146

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scholarly article

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10.1042/BST20120138

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5

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40

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Sabine Hilfiker

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2012-10-01T00:00:00Z

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22988879

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