GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
about
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityGTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamilyRAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskAn early endosome regulator, Rab5b, is an LRRK2 kinase substrateUnbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson diseaseActivation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsLrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp.Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationParkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.ARFGAP1 is dynamically associated with lipid droplets in hepatocytesDysregulation of protein trafficking in neurodegeneration.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesIdentification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expressionActivation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.Cellular effects of LRRK2 mutations.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.Contribution of GTPase activity to LRRK2-associated Parkinson diseaseMitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.The GTPase function of LRRK2.LRRK2 and vesicle trafficking.A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation.Interaction of LRRK2 with kinase and GTPase signaling cascadesLRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunctionLRRK2 Pathways Leading to Neurodegeneration.LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.
P2860
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P2860
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@ast
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en-gb
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@nl
type
label
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@ast
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en-gb
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@nl
altLabel
GTPase Activity and Neuronal T ...... LRRK2 Is Regulated by ArfGAP1
@en
prefLabel
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@ast
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en-gb
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@nl
P2093
P2860
P921
P3181
P1433
P1476
GTPase activity and neuronal t ...... LRRK2 is regulated by ArfGAP1
@en
P2093
Darren J Moore
Klodjan Stafa
Liliane Glauser
Philip J Webber
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002526
P407
P577
2012-01-01T00:00:00Z