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Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityMolecular chaperones: guardians of the proteome in normal and disease statesThe nucleotide exchange factors of Hsp70 molecular chaperonesRNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional ProteinsBiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functionsThe role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognitionStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketA chaperome subnetwork safeguards proteostasis in aging and neurodegenerative diseaseThe Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's DiseaseSubstrate-binding domain conformational dynamics mediate Hsp70 allosteryLarge-Scale Conformational Transitions and Dimerization Are Encoded in the Amino-Acid Sequences of Hsp70 ChaperonesHSP70 regulates the function of mitotic centrosomesARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradationHeterogeneous binding of the SH3 client protein to the DnaK molecular chaperone.A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Pathways of allosteric regulation in Hsp70 chaperones.Proteomic analysis of exported chaperone/co-chaperone complexes of P. falciparum reveals an array of complex protein-protein interactionsCrowding activates ClpB and enhances its association with DnaK for efficient protein aggregate reactivation.Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumptionHierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.Emerging features of ER resident J-proteins in plants.Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysisSingle-molecule spectroscopy reveals chaperone-mediated expansion of substrate protein.The specialized Hsp70 (HscA) interdomain linker binds to its nucleotide-binding domain and stimulates ATP hydrolysis in both cis and trans configurations.ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.Roles of intramolecular and intermolecular interactions in functional regulation of the Hsp70 J-protein co-chaperone Sis1.Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotypeTangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.Differential protein expression in Phalaenopsis under low temperature.Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent PathwaysMulti-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperonesHuman Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes.Dancing through Life: Molecular Dynamics Simulations and Network-Centric Modeling of Allosteric Mechanisms in Hsp70 and Hsp110 Chaperone Proteins.Mapping the conformation of a client protein through the Hsp70 functional cycle.Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Functionality of Class A and Class B J-protein co-chaperones with Hsp70.Computational Analysis of Residue Interaction Networks and Coevolutionary Relationships in the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and CommunicationProteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Hsp70 chaperone dynamics and molecular mechanism.
@en
type
label
Hsp70 chaperone dynamics and molecular mechanism.
@en
prefLabel
Hsp70 chaperone dynamics and molecular mechanism.
@en
P1476
Hsp70 chaperone dynamics and molecular mechanism.
@en
P2093
Matthias P Mayer
P304
P356
10.1016/J.TIBS.2013.08.001
P577
2013-09-05T00:00:00Z