Polypharmacology: challenges and opportunities in drug discovery.
about
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionStudying epigenetic complexes and their inhibitors with the proteomics toolboxDrug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening MethodologiesMultiple Targeting Approaches on Histamine H3 Receptor AntagonistsDrug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric DisordersSystems psychopharmacology: A network approach to developing novel therapiesSynthetic biology for pharmaceutical drug discoveryEpigenetic polypharmacology: from combination therapy to multitargeted drugsIncorporating Natural Products, Pharmaceutical Drugs, Self-Care and Digital/Mobile Health Technologies into Molecular-Behavioral Combination Therapies for Chronic DiseasesRepositioning of Thiourea-Containing Drugs as Tyrosinase InhibitorsDiscovery and development of natural product oridonin-inspired anticancer agentsSimilarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological ProfileLigand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual ScreeningModeling-Enabled Characterization of Novel NLRX1 LigandsA Multilayer Network Approach for Guiding Drug Repositioning in Neglected DiseasesNetwork-Based Approach to Identify Potential Targets and Drugs that Promote Neuroprotection and Neurorepair in Acute Ischemic StrokeBIGCHEM: Challenges and Opportunities for Big Data Analysis in ChemistryLeveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.Structural insights into the polypharmacological activity of quercetin on serine/threonine kinasesInvestigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy.The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity dataPhytochemicals Approach for Developing Cancer Immunotherapeutics.Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?Computational studies to predict or explain G protein coupled receptor polypharmacologyDiscovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase InhibitorsThe design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.Identification of orthologous target pairs with shared active compounds and comparison of organism-specific activity patterns.Quantifying the tendency of therapeutic target proteins to bind promiscuous or selective compoundsAcute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy.Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.Chemical genetics and regeneration.Non-stoichiometric inhibition in integrated lead finding - a literature review.One size does not fit all: Challenging some dogmas and taboos in drug discovery.Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancementDrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.Probing an Allosteric Pocket of CDK2 with Small Molecules.The use of novel selectivity metrics in kinase research.Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets.Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands.
P2860
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P2860
Polypharmacology: challenges and opportunities in drug discovery.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Polypharmacology: challenges and opportunities in drug discovery.
@en
type
label
Polypharmacology: challenges and opportunities in drug discovery.
@en
prefLabel
Polypharmacology: challenges and opportunities in drug discovery.
@en
P356
P1476
Polypharmacology: challenges and opportunities in drug discovery.
@en
P2093
Andrew Anighoro
Giulio Rastelli
P304
P356
10.1021/JM5006463
P407
P577
2014-06-25T00:00:00Z