Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.
about
Recent advances in understanding hepatic drug transportSandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid.Transporter assays as useful in vitro tools in drug discovery and development.Computational modeling to predict the functions and impact of drug transporters.Comparing Various In Vitro Prediction Criteria to Assess the Potential of a New Molecular Entity to Inhibit Organic Anion Transporting Polypeptide 1B1.Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Evaluation of the Interplay between Uptake Transport and CYP3A4 Induction in Micropatterned Cocultured Hepatocytes.Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.Does the Systemic Plasma Profile Inform the Liver Profile? Analysis Using a Physiologically Based Pharmacokinetic Model and Individual Compounds.Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapeVerapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.A Mechanistic Pharmacokinetic Model for Liver Transporter Substrates Under Liver Cirrhosis Conditions.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.Role of enterohepatic recirculation in drug disposition: cooperation and complications.Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice.
P2860
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P2860
Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.
description
2014 nî lūn-bûn
@nan
2014年の論文
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2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
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name
Prediction of pharmacokinetics ...... tic transporters are involved.
@en
type
label
Prediction of pharmacokinetics ...... tic transporters are involved.
@en
prefLabel
Prediction of pharmacokinetics ...... tic transporters are involved.
@en
P2093
P2860
P1476
Prediction of pharmacokinetics ...... tic transporters are involved.
@en
P2093
Hugh A Barton
Manthena V Varma
P2860
P2888
P304
P356
10.1007/S40262-014-0156-Z
P577
2014-08-01T00:00:00Z
P6179
1039061426