Structural implications of β-cardiac myosin heavy chain mutations in human disease.
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Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effectorRecent advances in muscle researchHarmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin moleculesBiophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurinModulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.Actomyosin based contraction: one mechanokinetic model from single molecules to muscle?Myofilaments: Movers and Rulers of the Sarcomere.Impact of Non-Human Leukocyte Antigen-Specific Antibodies in Kidney and Heart Transplantation.Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation.Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.The contribution of mutations in MYH7 to the onset of cardiomyopathy.The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease.Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo.A1603P and K1617del, Mutations in β-Cardiac Myosin Heavy Chain that Cause Laing Early-Onset Distal Myopathy, Affect Secondary Structure and Filament Formation In Vitro and In Vivo.A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibitionProlonged cross-bridge binding triggers muscle dysfunction in a model of myosin-based hypertrophic cardiomyopathy
P2860
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P2860
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
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2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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name
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en-gb
type
label
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en-gb
prefLabel
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en-gb
P2860
P356
P1476
Structural implications of β-cardiac myosin heavy chain mutations in human disease.
@en
P2093
Melanie Colegrave
P2860
P304
P356
10.1002/AR.22973
P577
2014-09-01T00:00:00Z