Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.
about
Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function.Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kExtracellular regulated kinase (ERK)-dependent regulation of sialomucin complex/rat Muc4 in mammary epithelial cellsGrowth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Genetically engineered rodent models of mammary gland carcinogenesis: an overview.Elevated circulating IGF-I promotes mammary gland development and proliferation.PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium.Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cellsSuppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.Unbound (bioavailable) IGF1 enhances somatic growth.Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.Apoptosis regulation in the mammary gland.Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice.Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signalingInsulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1.Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo.Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.Mammary involution and breast cancer risk: transgenic models and clinical studies.Roles of Fas and Fas ligand during mammary gland remodeling.Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal developmentCyclic-glycine-proline accelerates mammary involution by promoting apoptosis and inhibiting IGF-1 function.Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention.Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo.Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.
P2860
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P2860
Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Targeted expression of des(1-3 ...... GF-binding protein expression.
@en
type
label
Targeted expression of des(1-3 ...... GF-binding protein expression.
@en
prefLabel
Targeted expression of des(1-3 ...... GF-binding protein expression.
@en
P2093
P1433
P1476
Targeted expression of des(1-3 ...... GF-binding protein expression.
@en
P2093
Baumrucker CR
Fligger JM
Greenberg NM
Hadsell DL
P304
P356
10.1210/ENDO.137.1.8536631
P407
P577
1996-01-01T00:00:00Z