Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation.
about
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASPCortactin branches out: roles in regulating protrusive actin dynamicsThe interplay between the proteolytic, invasive, and adhesive domains of invadopodia and their roles in cancer invasionCells activated for wound repair have the potential to direct collective invasion of an epithelium.Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradationCortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistenceProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateRegulation of invasive behavior by vascular endothelial growth factor is HEF1-dependentNEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasisSpatiotemporal regulation of Src and its substrates at invadosomesCortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturationN-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cellsArg interacts with cortactin to promote adhesion-dependent cell edge protrusionSrc-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblastsFAK competes for Src to promote migration against invasion in melanoma cells.Further insights into cortactin conformational regulationp140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.The Aarskog-Scott syndrome protein Fgd1 regulates podosome formation and extracellular matrix remodeling in transforming growth factor β-stimulated aortic endothelial cells.Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.β1A integrin is a master regulator of invadosome organization and function.The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo.Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.Interactions with actin monomers, actin filaments, and Arp2/3 complex define the roles of WASP family proteins and cortactin in coordinately regulating branched actin networksNck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivop53 in cell invasion, podosomes, and invadopodiaHIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood-brain barrier interactions: modulatory role of CCR5Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression.Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodiaSaracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia FunctionImportance of RhoGTPases in formation, characteristics, and functions of invadosomes.Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.Abl kinases are required for invadopodia formation and chemokine-induced invasion.Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodiaERK5 signalling in prostate cancer promotes an invasive phenotype.An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.Twist1-induced invadopodia formation promotes tumor metastasis.
P2860
Q24313584-6DB29B4A-A8A3-4650-BD06-E96373E3AF55Q24322605-5E0CF50C-1815-41F4-A0C9-20CDD7671383Q24657822-A19A78A8-3A9C-40CB-926A-88DD0A49751DQ27003744-CA03D0B6-B6A9-4116-B02A-65084B63C3DFQ27305106-073FB4A3-60C8-4003-88B5-60048B4F2049Q27316558-D0DFBDFB-B38D-477D-8F10-E84CA016DFCEQ27316921-9056F4CB-F0A7-43CF-BF9C-786662404B5AQ28115210-4D5048F2-53A7-494E-AD0C-D8B115451170Q28283260-F5D148EC-695C-4EA5-A04C-D90704A00D8EQ28301472-B6F7A825-7DD6-440E-88D1-B08D6D8941AFQ28391160-BF8C6743-ADF8-4DD2-89CC-4EC9BA266E75Q28508669-62E42B01-614D-49A1-8C06-6AC8326CB31BQ28571875-F21CB0BD-EF75-4F40-BAF9-14F8E20ACB52Q28585696-42DDE787-9F6B-4197-AC18-12D2CF5813A2Q28586428-6CB15F0C-5F19-4D59-835E-8F98D56D9F04Q30009333-C54B2DA7-1906-4E16-B1C4-3B490A36D469Q30010248-703F0ACC-B842-4DD7-879F-89FEDCD057A6Q30010279-385BB9E1-954B-459A-B06B-41C56194E426Q30157203-8E5511E5-2A72-40CB-8E07-62EEB23996E2Q30427158-0CB5C4B2-E490-48F8-94EB-97624D5DC055Q30485711-4495089B-24A2-42F4-96C3-9180FF665AC5Q30494945-D3A22D88-AECC-4CF7-96CC-A62E56F34778Q30497504-11BE34CF-6670-4F44-9C7C-B7DF3BE668F1Q30540534-AF5F3BD2-0F96-4071-98E3-96465EDAC653Q30570530-1DFE74EB-4986-4EF4-B173-456935CE35C8Q30582998-42A76560-7556-408E-9E85-4714734FAC4DQ30593472-928CCAFC-3078-4CAD-AC40-FD0CB89B783EQ31033276-92B0EEB7-2245-42B8-A4C4-8277E3AFFC3CQ33358202-7C49AAAF-6F4D-4A28-98F8-0A6A8F7436E5Q33588957-98226130-13DC-4189-884A-2B8FD52FB7CDQ33685488-1CD026DB-70FB-470E-B8CD-36E39965D26FQ33840016-41D47928-7587-4CC7-972F-C26E83A3CF2EQ33873546-A64294D4-C16E-4501-933D-8D1AE079E8EEQ33968821-FE5B0436-8292-4132-85D8-95EE8C66AAB8Q34273690-5DE46242-7C2F-44CE-BDE5-7C33AB930A3DQ34401096-CFD94C71-DCB3-47C0-B927-4D1E7050D060Q34565948-BD2FE60D-F7D2-4B6C-828C-F469A4A0B404Q34627879-EF1EBEFE-7871-40EF-A2DF-69B5DF72CA16Q34670759-C36564CB-5C0C-4111-912E-C2B35194D1A8Q34770401-C62DFFB6-9492-479F-8D71-459E3052F662
P2860
Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Multiple regulatory inputs con ...... racellular matrix degradation.
@en
type
label
Multiple regulatory inputs con ...... racellular matrix degradation.
@en
prefLabel
Multiple regulatory inputs con ...... racellular matrix degradation.
@en
P2093
P50
P356
P1476
Multiple regulatory inputs con ...... tracellular matrix degradation
@en
P2093
Giada Giacchetti
Giusi Caldieri
Massimiliano Baldassarre
Stefano Tetè
P304
P356
10.1242/JCS.008037
P407
P577
2008-01-15T00:00:00Z