Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.
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Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cellsPurification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cellsGlucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localizationGlucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells.Gene expression in pancreatic adenocarcinoma.p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.Pancreatic development and adult diabetes.GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish.Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3.Short-term regulation of insulin gene transcription by glucose.Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.The caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells.Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretionPDX-1 interaction and regulation of the Pancreatic Derived Factor (PANDER, FAM3B) promoter.Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cellsThermodynamic and structural determinants of differential Pdx1 binding to elements from the insulin and IAPP promoters.Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS.The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.Regulation of insulin gene expression by overlapping DNA-binding elements.The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression.Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells.Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor.Individual beta cells within the intact islet differentially respond to glucose.cAMP prevents the glucose-mediated stimulation of GLUT2 gene transcription in hepatocytes.Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter.Pancreatic development and maturation of the islet B cell. Studies of pluripotent islet cultures.Functional analysis of a newly identified TAAT-box of the rat insulin-II gene promoter.
P2860
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P2860
Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Glucose modulates the binding ...... sphorylation-dependent manner.
@en
type
label
Glucose modulates the binding ...... sphorylation-dependent manner.
@en
prefLabel
Glucose modulates the binding ...... sphorylation-dependent manner.
@en
P2093
P2860
P356
P1433
P1476
Glucose modulates the binding ...... sphorylation-dependent manner.
@en
P2093
I Bujalska
M Gilligan
W M MacFarlane
P2860
P304
P356
10.1042/BJ3030625
P407
P478
303 ( Pt 2)
P577
1994-10-01T00:00:00Z