Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
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AOBase: a database for antisense oligonucleotides selection and design.Transcription factor Egr-1 regulates glomerular mesangial cell proliferationDetermination of optimal sites of antisense oligonucleotide cleavage within TNFalpha mRNA.A genomic selection strategy to identify accessible and dimerization blocking targets in the 5'-UTR of HIV-1 RNASelection of antisense oligonucleotides based on multiple predicted target mRNA structures.Antisense DNA parameters derived from next-nearest-neighbor analysis of experimental data.Reduction of target gene expression by a modified U1 snRNA.Prioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsA rapid in vitro method for obtaining RNA accessibility patterns for complementary DNA probes: correlation with an intracellular pattern and known RNA structuresPotent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.Bioconjugation of oligonucleotides for treating liver fibrosis.Antisense oligodeoxynucleotides selectively suppress expression of the mutant alpha 2(I) collagen allele in type IV osteogenesis imperfecta fibroblasts. A molecular approach to therapeutics of dominant negative disorders.Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.Effects of RNA secondary structure on cellular antisense activity.Antisense oligonucleotides containing modified bases inhibit in vitro translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin.Triple helix-forming oligonucleotide corresponding to the polypyrimidine sequence in the rat alpha 1(I) collagen promoter specifically inhibits factor binding and transcription.Receptor-mediated hepatic uptake of M6P-BSA-conjugated triplex-forming oligonucleotides in rats.siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells.Inhibitory effects of antisense oligonucleotides on the expression of procollagen type III gene in mouse hepatic stellate cells transformed by simian virus 40.Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging.Ezrin mRNA target site selection for DNAzymes using secondary structure and hybridization thermodynamics.Transfer of proalpha2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of alpha1(I) and alpha2(I) heterotrimers in vitro and in vivo.Attenuation of alpha1 collagen production with antisense ribonucleic acid in cultured hypertrophic scar fibroblasts.Autocrine transforming growth factor beta stimulation of extracellular matrix production by fibroblasts from fibrotic human gingiva.
P2860
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P2860
Specific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Specific inhibition of express ...... ondary structure for the mRNA.
@en
type
label
Specific inhibition of express ...... ondary structure for the mRNA.
@en
prefLabel
Specific inhibition of express ...... ondary structure for the mRNA.
@en
P2093
P356
P1433
P1476
Specific inhibition of express ...... ondary structure for the mRNA.
@en
P2093
P304
11033-11039
P356
10.1021/BI00202A024
P407
P577
1994-09-01T00:00:00Z