Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. - Wikidata - awgldk - TriplyDB

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

http://www.wikidata.org/entity/Q38312576

about

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Structure of mammalian AMPK and its regulation by ADP AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity AMP-activated protein kinase, stress responses and cardiovascular diseases The AMPK signalling pathway coordinates cell growth, autophagy and metabolism The ancient drug salicylate directly activates AMP-activated protein kinase Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity AMPK activators: mechanisms of action and physiological activities Regulation of AMP-activated protein kinase by natural and synthetic activators AMPK as a potential anticancer target - friend or foe?AMP-activated protein kinase: a target for drugs both ancient and modern Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?AMPK: a target for drugs and natural products with effects on both diabetes and cancer Cellular and molecular mechanisms of metformin: an overview AMPK: An emerging target for modification of injury-induced pain plasticity.Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats Structural basis of AMPK regulation by small molecule activators AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity Activation of AMPK by bitter melon triterpenoids involves CaMKKβ Shizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunction Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle The LKB1-AMPK pathway: metabolism and growth control in tumour suppression Treatment of nonalcoholic fatty liver disease: role of AMPK.Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.Development of novel adenosine monophosphate-activated protein kinase activators.High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.Effect of different γ-subunit isoforms on the regulation of AMPK EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.

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P2860

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

http://www.wikidata.org/entity/Q38312576

description

2006 nî lūn-bûn

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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Identification and characteriz ...... es and the metabolic syndrome.

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Identification and characteriz ...... es and the metabolic syndrome.

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Identification and characteriz ...... es and the metabolic syndrome.

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J.CMET.2006.05.005

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Cell Metabolism

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Identification and characteriz ...... es and the metabolic syndrome.

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Andrew Adler

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Barbara Cool

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Bradley Zinker

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Ernst Frevert

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Gang Zhao

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Gerard Gagne

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Heidi S Camp

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Kennan Marsh

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Lemma Kifle

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Matthew Perham

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403-416

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scholarly article

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10.1016/J.CMET.2006.05.005

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7028586

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type-2 diabetes

metabolic syndrome